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Blindness:
Fantastic Four - comics/movies - Alicia Masters
Star Trek: The Next Generation - tv - Geordi LaForge
Dyslexia:
Heroes - tv - Matt Parkman (one of the main cast)
The Cosby Show - tv - Theo Huxtable
Dawn and Whitney, Friends Forever, one of the Babysitters Club stories, features a girl with Down Syndrome as well.