Malcolm In The Middle - Malcolm's best friend is in a wheel chair.

And Marlee Maitlin had a major recurring role on West Wing as a pollster who actually used a translator.

Whistler is the blind phreak genius in the movie Sneakers (Robert Redford).

Monk is OCD, agoraphobic.

Professor Xavier of X-Men is a paraplegic.

Daredevil is blind.

Johnny Smith of Dead Zone walks with a limp and has a physical therapist as one of his supporting characters.

Dexter is a sociopath who has found unique coping methods. Oh wait, scratch that one.