Black - Bollywood movie (really different from the usual BW and without songs actually). It's inspired by Helen Keller's autobiography so it is basically the story of a deaf and mute girl.

Itoshi Kimi e - jdrama. Main lead gets Behçet's disease and loses sight.

Edison no Haha - jdrama. Not disability but about a boy who is too intelligent for his age and how the school, and especially his teacher deals with it.

Nodame Cantabile - jdrama. Nodame could possibly be on the autism spectrum.