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Date: 2009-01-03 05:35 am (UTC)Logan from Dark Angel was paraplegic and in a wheelchair.
Whatserface from Birds of Prey -- comic or shortlived tv show, take your pick -- was also paralyzed and wheelchair bound
Annie, the blind girl on Dark Angel for one episode (second season), played by Dee from BSG.
Ike from Young Riders is mute.
Did anyone mention Corky from Life Goes On with Downs Syndrome?